Entrepreneurship in global knowledge-based economies (KBEs) plays a pivotal role in advancing sustainable development, yet its mechanisms and implications remain underexplored. This study investigates how entrepreneurs leverage innovation and global networks to drive sustainable outcomes within KBEs, aligning with Sustainable Development Goals (SDGs). Utilizing a mixed-methodology framework, encompassing case analyses and stakeholder questionnaires, the study investigates enterprises in technology, sustainable energy, and social ventures across various geographical areas. Findings reveal that knowledge-intensive entrepreneurship fosters economic growth, environmental sustainability, and social inclusion through innovative business models, though challenges like funding constraints and regulatory complexities persist (1). The study proposes strategies such as supportive policies, public-private collaborations, and education programs to enhance sustainable entrepreneurship (2). Theoretically, it refines frameworks by integrating Schumpeterian innovation and stakeholder theories, offering a global perspective on sustainable entrepreneurship (3). Practically, it provides actionable recommendations for entrepreneurs and policymakers to strengthen KBE ecosystems (4). The research underscores the transformative potential of entrepreneurship in achieving SDGs, advocating for global collaboration to foster a sustainable future (5).