Tubittumjournal
Background: Hypertriglyceridemia is a major risk factor for cardiovascular and metabolic disorders. Matricaria chamomilla (Chamomile), a widely used medicinal herb, possesses antioxidant, anti-inflammatory, and lipid-modulating properties. Its specific effects on serum triglyceride levels, however, remain to be systematically evaluated.
Objective: This systematic review aims to comprehensively assess the pharmacological and therapeutic effects of Matricaria chamomilla on serum triglyceride levels across human, animal, and in vitro studies.
Methods: A structured literature search was conducted in PubMed, Scopus, and Web of Science up to 2025. Studies evaluating Chamomile’s impact on triglyceride levels were included. Data extraction and quality assessment were independently performed by two reviewers using Cochrane Risk of Bias and Newcastle–Ottawa Scale tools. Findings were synthesized qualitatively, and meta-analysis was performed where appropriate.
Results: Ten studies met inclusion criteria, including 4 human clinical trials, 4 animal studies, and 2 in vitro investigations. Chamomile consistently reduced serum triglyceride levels in animal models and showed moderate lipid-lowering effects in humans. Mechanistic evidence indicates its effects are mediated through antioxidant activity, modulation of lipid-metabolizing enzymes, and anti-inflammatory pathways. Reported adverse effects were minimal and mild.
Conclusion: Current evidence supports Matricaria chamomilla as a potential adjunct therapy for hypertriglyceridemia. High-quality randomized controlled trials are needed to establish optimal dosing, treatment duration, and long-term safety.
Health promotion through lifestyle is at the heart of modern preventive medicine. Iranian Traditional Medicine (ITM), with its centuries-old wisdom, offers a culturally grounded model for achieving well-being. This review explores ITM’s approach to lifestyle through Setteh-e-Zaruriyyeh—six essential principles of health—and their relevance to modern challenges. By integrating concepts like Mizaj (temperament) and reviewing clinical studies, we show how ITM aligns with contemporary strategies. The paper concludes with suggestions for integrating ITM into public health frameworks.
Entrepreneurship in global knowledge-based economies (KBEs) plays a pivotal role in advancing sustainable development, yet its mechanisms and implications remain underexplored. This study investigates how entrepreneurs leverage innovation and global networks to drive sustainable outcomes within KBEs, aligning with Sustainable Development Goals (SDGs). Utilizing a mixed-methodology framework, encompassing case analyses and stakeholder questionnaires, the study investigates enterprises in technology, sustainable energy, and social ventures across various geographical areas. Findings reveal that knowledge-intensive entrepreneurship fosters economic growth, environmental sustainability, and social inclusion through innovative business models, though challenges like funding constraints and regulatory complexities persist (1). The study proposes strategies such as supportive policies, public-private collaborations, and education programs to enhance sustainable entrepreneurship (2). Theoretically, it refines frameworks by integrating Schumpeterian innovation and stakeholder theories, offering a global perspective on sustainable entrepreneurship (3). Practically, it provides actionable recommendations for entrepreneurs and policymakers to strengthen KBE ecosystems (4). The research underscores the transformative potential of entrepreneurship in achieving SDGs, advocating for global collaboration to foster a sustainable future (5).