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Impact of Herbal Compounds on Human Gut Microbiota: A Comprehensive Review

Vol 5, issue 1, 2026

Authors

  • Mojtaba Valizadegan Arjomand
  • Maryam Madani Asl
  • Reza Faraji Meydani
  • Khadije Soltani langarani
  • Diako Ghazizadeh
  • Ali Piran
  • Mehran Rostam Zaman
Mojtaba Valizadegan Arjomand
Maryam Madani Asl
Khadije Soltani langarani
Diako Ghazizadeh
Ali Piran
Mehran Rostam Zaman

Abstract

Abstract

Background and Objective: The human gastrointestinal tract harbors a complex and dynamic community of microorganisms collectively known as the intestinal microbiota, which plays a crucial role in maintaining metabolic, immunological, and physiological homeostasis. These microorganisms regulate essential bodily functions, including digestion, nutrient absorption, immune modulation, and protection against pathogenic organisms. Disruption of the intestinal microbial balance (dysbiosis) has been increasingly associated with a wide range of diseases, such as metabolic disorders, inflammatory conditions, autoimmune diseases, and gastrointestinal dysfunctions. In recent years, growing scientific interest has focused on the potential of medicinal plants and bioactive herbal compounds to modulate gut microbiota composition, enhance beneficial microbial populations, and restore intestinal homeostasis. Understanding the interaction between herbal compounds and gut microbiota may provide novel, safe, and complementary therapeutic strategies for the prevention and management of microbiota-related diseases.

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Valizadegan Arjomand M, Madani Asl M, Faraji Meydani R, Soltani langarani KH, Ghazizadeh D, Piran A, Rostam Zaman M. Impact of Herbal Compounds on Human Gut Microbiota: A Comprehensive Review. 2026;5(1):159-174. DOI:10.64209/tubittum.v5i1.1122

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Refrences:

  1. Fariba Kohdani, Hanieh Al-Sadat Ejtahed, Kamelia Akhgarjand, Amir Bagheri, Ahmad Jaidi, Farideh Shirasab, Atiyeh Mirzababai, Seyyed Mohammad Mousavi. Microbiome and health book, Tehran, Naqsh Ivan, introduction, 2022.

2. Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature. 2012; 489(7415): 220-30.

  1. Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J. 2017; 474(11): 1823-36. 4.Gerritsen J, Smidt H, Rijkers GT, de Vos WM. Intes tinal microbiota in human health and disease: the impact of probiotics. Genes Nutr. 2011; 6(3): 209-40.
  2. Thaiss CA, Zmora N, Levy M, Elinav E. The microbiome and innate immunity. Nature. 2016; 535(7610): 65-74.
  3. Fujimura KE, Slusher NA, Cabana MD, Lynch SV. Role of the gut microbiota in defining human health. Expert Rev Anti Infect Ther. 2010; 8(4): 435-54.
  4. Borre YE, Moloney RD, Clarke G, Dinan TG, Cryan JF. The Impact of microbiota on brain and behavior: mechanisms & therapeutic potential. in: lyte m, cryan jf, editors. microbial endocrinology: the microbiotagut-brain axis in health and disease. New York, NY: Springer New York; 2014. p. 373-403.
  5. Putignani L, Del Chierico F, Petrucca A, Vernocchi P, Dallapiccola B. The human gut microbiota: a dynamic interplay with the host from birth to senescence settled during childhood. Pediatr Res. 2014; 76(1): 2-10.
  6. Neufeld KA, Fo s ter JA. Effects of gut microbiota on the brain: implications for psychiatry. J Psychiatry Neurosci. 2009; 34(3): 230-1.
  7. Foster JA, Rinaman L, Cryan JF. Stress & the gut-brain axis: Regulation by the microbiome. Neurobiol Stress. 2017; 7: 124-36.
  8. Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015; 28(2): 203-9.
  9. Xiao P. A Modeling Study in the Regulation of Stress on Neuronal Plasticity: The University of Texas at Arlington, 2015.

13.Mokhtari S, Jafari SM, Khomeiri M, Maghsudlou Y, Ghorbani M. The cell wall compound of Saccharomyces cerevisiae as a novel wall material for encapsulation of probiotics. Food Research International.2017;96:19-26.

  1. Strati F, Cavalieri D, Albanese D, De Felice C, Donati C, Hayek J, et al. New evidences on the altered gut microbiota in autism spectrum disorders. Microbiome. 2017; 5(1): 24. doi: 10.1186/s40168-017 0242-1. 10
  2. Li Q, Han Y, Dy ABC, Hagerman RJ. The gut microbiota and autism spectrum disorders. Front Cell Neurosci. 2017; 11: 120. doi: 10.3389/fncel.2017.00120.
  3. Clark A, Mach N. Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes. J Int Soc Sports Nutr. 2016; 13: 43. doi. org/10.1186/s12970-016-0155-6.
  4. Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 2012; 13(10): 701-12.
  5. Tillisch K, Labus J, Kilpatrick L, Jiang Z, Stains J, Ebrat B, et al. Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology. 2013; 144(7): 1394-401.
  6. Sampson TR, Mazmanian SK. Control of brain development, function, and behavior by the microbiome. Cell Host Microbe. 2015; 17(5): 565-76.

20.Dinan TG, Cryan JF. Gut-brain axis in 2016: Brain-gut-microbiota axis – mood, metabolism and behaviour. Nat Rev Gastroenterol Hepatol. 2017; 14(2): 69-70.

  1. Byrne CS, Chambers ES, Morrison DJ, Frost G. The role of short chain fatty acids in appetite regulation and energy homeostasis. Int J Obes (Lond). 2015; 39(9): 1331-8.
  2. Vuong HE, Yano JM, Fung TC, Hsiao EY. The microbiome and host behavior. Annu Rev Neurosci. 2017; 40: 21-49.
  3. Ressler KJ. Amygdala activity, fear, and anxiety: modulation by stress. Biol Psychiatry. 2010; 67(12): 1117-9.
  4. Qin J, Li R, Raes J, Arumugam M, Burgdorf Ks, Manichanh C, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464(7285):59-65.
  5. Arevalo-Rodriguez I, Smailagic N, i Figuls MR, Clapooni A,Sanchez-Perez E, Giannakou A, et al. Mini Mental State Examination (MMSE) for the detection of Alzheimers disease and other dementias in people with mild cognitive impairment (MCI). Cochrane Database of Systematic Reviews. 2015(3).
  6. Lanctot KL, Herrmann N, Mazzotta P, Khan LR, Ingber N, GABAergic function in Alzheimers disease: evidence for dysfunction and potential as a therapeutic target for the treatment of behavioural and psychological symptoms of dementia. The Canadian Journal of Psychiatry. 2004;49(7)439-53.
  7. Alegre ML, Mannon RB, Mannon PJ. The microbiota, the immune system and the allograft. Am J Transplant. 2014; 14(6): 1236-48.
  8. Klukowski M, Wasilewska J, Lebensztejn D. Sleep and gastrointestinal disturbances in autism spectrum disorder in children. Developmental period medicine. 2015;19(2):157-61.
  9. Wang L, Christophersen CT, Sorich MJ, Gerber JP, Angley MT, Conlon MA, Low relative abundances of the mucolytic bacterium Akkermansia muciniphila and Bifidobacterium spp. In faces of children with autism. Applied and rnvironmental microbiology.2011;77(18):6718-21.
  10. Guzman JD, Gupta A, Bucar F, Gibbons S, Bhakta S. Antimycobacterials from natural sources: ancient times, antibiotic era and novel scaffolds. Front Biosci 2012; 17(5): 1861 -1881 . 11
  11. Campanini -Salinas J, Andrades -Lagos J, Mella -Raipan J, Vasquez -Velasquez D. Novel classes of antibacterial drugs in clinical development, a hope in a post -antibiotic era. Current Topics in Medicinal Chemistry 2018; 18(14): 1188 -1202.
  12. Lee SJ, Bose S, Seo JG, Chung WS, Lim CY, Kim H. The effects of co -administration of probiotics with herbal medicine on obesity, metabolic endotoxemia and dysbiosis: a randomized double -blind controlled clinical trial. Clin Nutr 2014; 33(6): 973 -981 .
  13. Eyvazi S, Vostakolaei MA, Dilmaghani A, Borumandi O, Hejazi MS, Kahroba H, et al. The oncogenic roles of bacterial infections in development of cancer. Microbial Pathogenesis 2020; 141(8): 104019 .
  14. Simrén M. IBS with intestinal microbial dysbiosis: a new and clinically relevant subgroup Gut 2014; 63(11): 1685 -1686 .
  15. Hamedi A, Zarshenas MM, Sohrabpour M, Zargaran A. Herbal medicinal oils in traditional Persian medicine. Pharmaceutical Biology 2013; 51(9): 1208 -1218 .
  16. Abdullahi A, Khairulmazmi A, Yasmeen S, Ismail I, Norhayu A, Sulaiman M, et al. Phytochemical profiling and antimicrobial activity of ginger (Zingiber officinale) essential oils against important phytopathogens. Arabian Journal of Chemistry 2020; 13(11): 8012 -8025 .
  17. Wang X, Shen Y, Thakur K, Han J, Zhang J – G, Hu F, et al. Antibacterial activity and mechanism of ginger essential oil against Escherichia coli and Staphylococcus aureus. Molecules 2020; 25(17): 3955 .
  18. Mohammadzadeh F, Monirifar H, Saba J, Valizadeh M, Haghighi AR, Zanjani BM, et al. Genetic variation among Iranian alfalfa (Medicago sativa L.) populations based on RAPD markers. Bangladesh Journal of Plant Taxonomy 2011; 18(2): 93 -104 .
  19. Azargun R, Gholizadeh P, Sadeghi V, Hosainzadegan H, Tarhriz V, Memar MY, et al. Molecular mechanisms associated with quinolone resistance in Enterobacteriaceae: review and update. Transactions of the Royal Society of Tropical Medicine and Hygiene 2020; 114(10): 770 -781.
  20. Davis CP. Normal flora. Medical Microbiology 4 th ed . University of Texas Medical Branch at Galveston; 1996 .
  21. Vaishnavi C. Translocation of gut flora and its role in sepsis. Indian J Med Microbiol 2013; 31(4): 334 342.
  22. Nazzaro F, Fratianni F, De Martino L, Coppola R, De Feo V. Effect of essential oils on pathogenic bacteria. Pharmaceuticals 2013; 6(12): 1451 -1474 .
  23. Graich H, Amouch F, et al. Antibacterial activity of essential oils extracts from cinnamon, thyme, clove and geranium against a gram negative and gram positive pathogenic bacteria. Journal of Diseases and Medicinal Plants 2017; 3(2 -1): 1 – 5 .
  24. Soleimani N, Ebraze N. Evaluate anti – bacterial effects of cinnamomun verum and ferula gummosa essential oil on some pathogen gram positive and negative bacteria. New Cellular and Molecular Biotechnology Journal 2016; 6(23): 87 -94 (Persian) . 12
  25. Shukla R, Pahal S, Gupta A, Choudhary P, Misra K, Singh S.J Modulation of GPCR receptors common to gut inflammatory diseases and neuronal disorders, Alzheimer’s and Parkinson’s diseases as druggable targets through Withania somnifera bioactives: an in silico study Biomol Struct Dyn. 2023 Jul;41(10):4485-4503.
  26. Chatterjee SS, Kumar V. Quantitative systems pharmacology: Lessons from fumaric acid and herbal remedies. Drug Des. 2017;6:152.
  27. Kumar V, Thakur AK, Verma S, Yadav V, Chatterjee SS. Potential of some traditionally used edible plants for prevention and cure of disability associated comorbidities. TANG [Hum Med] 2015;5:8.1–8.22.
  28. Kumar V, Dey A, Chatterjee SS. Phytopharmacology of Ashwagandha as an anti-diabetic herb. In: Kaul S, Wadhwa R, editors. Science of Ashwagandha: Preventive and Therapeutic Potentials. Cham: Springer; 2017. pp. 37–68.
  29. Dey A, Chatterjee SS, Kumar V. Analgesic activity of a Withania somnifera extract in stressed mice. Orient Pharm Exp Med. 2016;16:295–302.
  30. Baliga, M.S.; Dsouza, J.J. Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer. Eur. J. Cancer Prev. 2011, 20, 225–239.
  31. Wang, C.C.; Yuan, J.R.; Wang, C.F.; Yang, N.; Chen, J.; Liu, D.; Song, J.; Feng, L.; Tan, X.B.; Jia, X.B. Anti inflammatory effects of Phyllanthus emblica L. on benzopyrene-induced precancerous lung lesion by regulating the IL-1β/miR-101/Lin28B signaling pathway. Integr. Cancer Ther. 2017, 16, 505–515.
  32. Saini, R.; Sharma, N.; Oladeji, O.S.; Sourirajan, A.; Dev, K.; Zengin, G.; El-Shazly, M.; Kumar, V. Traditional uses, bioactive composition, pharmacology, and toxicology of Phyllanthus emblica fruits: A comprehensive review. J. Ethnopharmacol. 2022, 282, 114570.
  33. Khan, A.; Ahmed, T.; Rizwan, M.; Khan, N. Comparative therapeutic efficacy of Phyllanthus emblica (Amla) fruit extract and procaine penicillin in the treatment of subclinical mastitis in dairy buffaloes. Microb. Pathog. 2018, 115, 8–11.
  34. Gunti, L.; Dass, R.S.; Kalagatur, N.K. Phytofabrication of selenium nanoparticles from Emblica officinalis fruit extract and exploring its biopotential applications: Antioxidant, antimicrobial, and biocompatibility. Front. Microbiol. 2019, 10, 931.

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