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Research Article

INVESTIGATION OF THE ACTIVE INGREDIENT OF THE PLANT LAVANDULA ANGUSTIFOLIA AND ITS PHYSICAL AND CHEMICAL PROPERTIES (REVIEW)

Authors

  • Behzad Jaybashi
  • Roya Hemmatpour
  •  Mehrdad Fojlaley
  •  Majid Rahimi
  • Faezeh Dorisefat
  • Massoumeh Eini

Abstract

Abstract

The use of medicinal plants has been increasing in recent years, especially in traditional and complementary medicine worldwide. Many of these medicinal plants are consumed without sufficient scientific backing, which can have consequences for people’s health and impose significant healthcare costs on the system. Among these, Lavandula angustifolia is one of the most common herbal medicines due to its widespread use in traditional medicine. The use of Lavandula angustifolia has been well demonstrated in various studies for some conditions such as anxiety disorders and sleep disorders. However, evidence for its effectiveness in treating other diseases is contradictory or limited. This study examines the importance of the active ingredient of Lavandula angustifolia and the processing and post-harvest methods in the food and pharmaceutical industries based on existing research.

 

 

Jaybashi B, Hemmatpour R, Fojlaley M, Rahimi M, Dorisefat F, Eini M. INVESTIGATION OF THE ACTIVE INGREDIENT OF THE PLANT LAVANDULA ANGUSTIFOLIA AND ITS PHYSICAL AND CHEMICAL PROPERTIES (REVIEW). Tubittum. 2024; 3(1): 521-530.

  1. Dabas A, Yadav P, Geetanjali, Singh R. Role of Herbal Medicine in Boosting Immune System. Role of Herbal Medicines: Management of Lifestyle Diseases: Springer; 2024. p. 389-401.
  2. Otimenyin SO. Herbal Medicine for the Management of Anxiety, Depression, and Insomnia. Role of Herbal Medicines: Management of Lifestyle Diseases: Springer; 2024. p. 251-69.
  3. Pan S-Y, Litscher G, Gao S-H, Zhou S-F, Yu Z-L, Chen H-Q, et al. Historical perspective of traditional indigenous medical practices: the current renaissance and conservation of herbal resources. Evidence-based complementary and alternative medicine. 2014;2014.
  4. Sharma A, Sabharwal P, Dada R. Herbal medicine—An introduction to its history. Herbal Medicine in Andrology: Elsevier; 2021. p. 1-8.
  5. Sumit K, Vivek S, Sujata S, Ashish B. Herbal cosmetics: used for skin and hair. Inven J. 2012;2012:1-7.
  6. Zhang Y, Zhang J, Yan J, Qi X, Wang Y, Zheng Z, et al. Application of fermented Chinese herbal medicines in food and medicine field: from an antioxidant perspective. Trends in Food Science & Technology. 2024:104410.
  7. Sendker J, Sheridan H. History and current status of herbal medicines. Toxicology of herbal products. 2017:11-27.
  8. Tayeb BA, Kusuma IY, Osman AA, Minorics R. Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer: A systematic review. Journal of Integrative Medicine. 2024.
  9. Koulivand PH, Khaleghi Ghadiri M, Gorji A. Lavender and the nervous system. Evidence-based complementary and alternative medicine. 2013;2013.
  10. Bai C, Yang J, Cao B, Xue Y, Gao P, Liang H, Li G. Growth years and post-harvest processing methods have critical roles on the contents of medicinal active ingredients of Scutellaria baicalensis. Industrial crops and products. 2020;158:112985.
  11. Zhu S, Shirakawa A, Shi Y, Yu X, Tamura T, Shibahara N, et al. Impact of different post-harvest processing methods on the chemical compositions of peony root. Journal of natural medicines. 2018;72:757-67.
  12. Dušková E, Dušek K, Indrák P, Smékalová K. Postharvest changes in essential oil content and quality of lavender flowers. Industrial Crops and Products. 2016;79:225-31.
  13. Tassew WC, Assefa GW, Zeleke AM, Ferede YA. Prevalence and associated factors of herbal medicine use among patients living with chronic disease in Ethiopia: A systematic review and meta-analysis. Metabolism Open. 2024:100280.
  14. Mosihuzzaman M. Herbal medicine in healthcare-an overview. Natural product communications. 2012;7(6):1934578X1200700628.
  15. Najafian S, Afshar M, Radi M. Annual Phytochemical variations and antioxidant activity within the aerial parts of Lavandula angustifolia, an evergreen medicinal plant. Chemistry & Biodiversity. 2022;19(10):e202200536.
  16. Upson T. The taxonomy of the genus Lavandula L. Lavender: CRC Press; 2002. p. 16-48.
  17. Héral B, Stierlin É, Fernandez X, Michel T. Phytochemicals from the genus Lavandula: A review. Phytochemistry Reviews. 2021;20:751-71.
  18. Kiprovski B, Zeremski T, Varga A, Čabarkapa I, Filipović J, Lončar B, Aćimović M. Essential oil quality of lavender grown outside its native distribution range: a study from Serbia. Horticulturae. 2023;9(7):816.
  19. Hassiotis C, Tarantilis P, Daferera D, Polissiou M. Etherio, a new variety of Lavandula angustifolia with improved essential oil production and composition from natural selected genotypes growing in Greece. Industrial Crops and Products. 2010;32(2):77-82.
  20. Brailko V, Mitrofanova O, Lesnikova-Sedoshenko N, Chelombit S, Mitrofanova I, editors. Anatomy studies of Lavandula angustifolia Mill. and Lavandula hybrida Rev. plants in vitro. AgroSym-2016; 2016.
  21. El-Sharnouby ME. Tolerance limits of lavender plant (LAVANDULA ANGUSTIFOLIA MILL) tissue cultures in response to abiotic stress. Pak J Bot. 2022;54(6):2063-8.
  22. Sönmez Ç, Şimşek Soysal A, Okkaoğlu H, Karık Ü, Taghiloofar AH, Bayram E. Determination of some yield and quality characteristics among individual plants of lavender (Lavandula angustifolia Mill.) populations grown under mediterranean conditions in Turkey. Pakistan Journal of Botany. 2018;50(6):2285-90.
  23. Góra J, Lis A, Gibka J, Wołoszyn A. Najcenniejsze olejki eteryczne: Wydawnictwo Uniwersytetu Mikołaja Kopernika; 2005.
  24. Batiha GE-S, Teibo JO, Wasef L, Shaheen HM, Akomolafe AP, Teibo TKA, et al. A review of the bioactive components and pharmacological properties of Lavandula species. Naunyn-schmiedeberg’s Archives of Pharmacology. 2023;396(5):877-900.
  25. Chen X, Zhang L, Qian C, Du Z, Xu P, Xiang Z. Chemical compositions of essential oil extracted from Lavandula angustifolia and its prevention of TPA-induced inflammation. Microchemical Journal. 2020;153:104458.
  26. Pokajewicz K, Białoń M, Svydenko L, Fedin R, Hudz N. Chemical composition of the essential oil of the new cultivars of Lavandula angustifolia Mill. Bred in Ukraine. Molecules. 2021;26(18):5681.
  27. Smigielski K, Prusinowska R, Stobiecka A, Kunicka-Styczyñska A, Gruska R. Biological properties and chemical composition of essential oils from flowers and aerial parts of lavender (Lavandula angustifolia). Journal of Essential Oil Bearing Plants. 2018;21(5):1303-14.
  28. Woronuk G, Demissie Z, Rheault M, Mahmoud S. Biosynthesis and therapeutic properties of Lavandula essential oil constituents. Planta medica. 2011;77(01):7-15.
  29. Da Porto C, Decorti D, Kikic I. Flavour compounds of Lavandula angustifolia L. to use in food manufacturing: Comparison of three different extraction methods. Food Chemistry. 2009;112(4):1072-8.
  30. Tundis R, Grande F, Occhiuzzi MA, Sicari V, Loizzo MR, Cappello AR. Lavandula angustifolia mill.(Lamiaceae) ethanol extract and its main constituents as promising agents for the treatment of metabolic disorders: chemical profile, in vitro biological studies, and molecular docking. Journal of Enzyme Inhibition and Medicinal Chemistry. 2023;38(1):2269481.
  31. Cardia GFE, Silva-Filho SE, Silva EL, Uchida NS, Cavalcante HAO, Cassarotti LL, et al. Effect of lavender (Lavandula angustifolia) essential oil on acute inflammatory response. Evidence-Based Complementary and Alternative Medicine. 2018;2018.
  32. Soheili M, Tavirani MR, Salami M. Lavandula angustifolia extract improves deteriorated synaptic plasticity in an animal model of Alzheimer’s disease. Iranian journal of basic medical sciences. 2015;18(11):1147.
  33. Kaka G, Yaghoobi K, Davoodi S, Hosseini SR, Sadraie SH, Mansouri K. Assessment of the neuroprotective effects of lavandula angustifolia extract on the contusive model of spinal cord injury in wistar rats. Frontiers in Neuroscience. 2016;10:25.
  34. Aboutaleb N, Jamali H, Abolhasani M, Toroudi HP. Lavender oil (Lavandula angustifolia) attenuates renal ischemia/reperfusion injury in rats through suppression of inflammation, oxidative stress and apoptosis. Biomedicine & pharmacotherapy. 2019;110:9-19.
  35. Ziaee M, Khorrami A, Ebrahimi M, Nourafcan H, Amiraslanzadeh M, Rameshrad M, et al. Cardioprotective effects of essential oil of Lavandula angustifolia on isoproterenol-induced acute myocardial infarction in rat. Iranian journal of pharmaceutical research: IJPR. 2015;14(1):279.
  36. López V, Nielsen B, Solas M, Ramírez MJ, Jäger AK. Exploring pharmacological mechanisms of lavender (Lavandula angustifolia) essential oil on central nervous system targets. Frontiers in pharmacology. 2017;8:280.
  37. Crișan I, Ona A, Vârban D, Muntean L, Vârban R, Stoie A, et al. Current trends for lavender (Lavandula angustifolia Mill.) crops and products with emphasis on essential oil quality. Plants. 2023;12(2):357.
  38. Erland LA, Mahmoud SS. Lavender (Lavandula angustifolia) oils. Essential oils in food preservation, flavor and safety. 2016:501-8.
  39. Mason J. Growing and knowing lavender: ACS Distance Education; 2014.
  40. Platt ES. Lavender: How to grow and use the fragrant herb: Stackpole Books; 2009.
  41. Muntean L, Tamas M, Muntean S, Muntean L, Duda M, Varban D, Florian S. A Treatise of Cultivated and Spontaneous Medicinal Plants; Risoprint: Cluj-Napoca. Romania. 2007:372.
  42. Barbieri C, Borsotto P. Essential oils: market and legislation. Potential of essential oils. 2018:107-27.
  43. Giray FH. An analysis of world lavender oil markets and lessons for Turkey. Journal of essential oil bearing plants. 2018;21(6):1612-23.
  44. Wells R, Truong F, Adal AM, Sarker LS, Mahmoud SS. Lavandula essential oils: A current review of applications in medicinal, food, and cosmetic industries of lavender. Natural Product Communications. 2018;13(10):1934578X1801301038.
  45. Peter KV. Handbook of herbs and spices: volume 3: Woodhead publishing; 2006.
  46. Gorgini Shabankareh H, Khorasaninejad S, Soltanloo H, Shariati V. Investigation of the effects of drought stress and abscisic acid foliar application on yield, physiological and biochemical properties of lavender (Lavandula angustifolia cv. Organic Munstead). Journal of Crop Production. 2021;14(2):65-82.
  47. Najar B, Demasi S, Caser M, Gaino W, Cioni PL, Pistelli L, Scariot V. Cultivation Substrate composition influences morphology, volatilome and essential oil of Lavandula angustifolia Mill. Agronomy. 2019;9(8):411.
  48. VÂRBAN R, Vârban DI, Stoie A, Bogdan I, Odagiu A, GHEȚE A. Identification of weed species present in lavender crops (Lavandula angustifolia L.) and (Mentha piperita L.) from the UASVM Cluj-Napoca campus. 2018.
  49. Vouzounis N, Dararas V, Georghiou G. Chemical control of weeds in the aromatic crops lavender, oregano and sage. Tech Bull. 2003(218):3–7.
  50. Radhakrishnan R, Alqarawi AA, Abd_Allah EF. Bioherbicides: Current knowledge on weed control mechanism. Ecotoxicology and environmental safety. 2018;158:131-8.
  51. Hasan M, Ahmad-Hamdani MS, Rosli AM, Hamdan H. Bioherbicides: An eco-friendly tool for sustainable weed management. Plants. 2021;10(6):1212.
  52. Giannoulis KD, Evangelopoulos V, Gougoulias N, Wogiatzi E. Lavender organic cultivation yield and essential oil can be improved by using bio-stimulants. Acta Agriculturae Scandinavica, Section B—Soil & Plant Science. 2020;70(8):648-56.
  53. Najar B, Pistelli L, Fratini F. Exploitation of marginal hilly land in Tuscany through the Cultivation of Lavandula angustifolia mill.: Characterization of its essential oil and antibacterial activity. Molecules. 2022;27(10):3216.
  54. Zheljazkov VD, Astatkie T, Hristov AN. Lavender and hyssop productivity, oil content, and bioactivity as a function of harvest time and drying. Industrial Crops and Products. 2012;36(1):222-8.
  55. Hassiotis CN, Lazari DM, Vlachonasios KE. The effects of habitat type and diurnal harvest on essential oil yield and composition of Lavandula angustifolia Mill. Fresenius Environmental Bulletin. 2010;19(8):1491-8.
  56. Mirjalili MH, Salehi P, Vala MM, Ghorbanpour M. The effect of drying methods on yield and chemical constituents of the essential oil in Lavandula angustifolia Mill.(Lamiaceae). Plant Physiology Reports. 2019;24:96-103.
  57. Łyczko J, Jałoszyński K, Surma M, García-Garví JM, Carbonell-Barrachina ÁA, Szumny A. Determination of various drying methods’ impact on odour quality of true lavender (Lavandula angustifolia Mill.) flowers. Molecules. 2019;24(16):2900.
  58. Rathore S, Kumar R. Essential oil content and compositional variability of Lavandula species cultivated in the mid hill conditions of the western himalaya. Molecules. 2022;27(11):3391.
  59. Tarakemeh A, Rowshan V, Najafian S. Essential oil content and composition of Lavandula angustifolia Mill. as affected by drying method and extraction time. Analytical Chemistry Letters. 2012;2(4):244-9.
  60. Mavandi P, Abbaszadeh B, Emami Bistgani Z, Barker AV, Hashemi M. Biomass, nutrient concentration and the essential oil composition of lavender (Lavandula angustifolia Mill.) grown with organic fertilizers. Journal of plant nutrition. 2021;44(20):3061-71.
  61. Sałata A. Supplementary irrigation and drying method affect the yield and essential oil content and composition of lavender (Lavandula angustifolia Mill.) flowers. Acta Scientiarum Polonorum Hortorum Cultus. 2020;19(6):139-51.
  62. Erbas S, Baydar H. Effects of harvest time and drying temperature on essential oil content and composition in lavandin (Lavandula x intermedia Emerice x Loisel.). Turkish Journal of Field Crops. 2008;13(1):24-31.
  63. Akcay S, Tunali S, GÜRBÜZ T, DAĞDELEN N. DETERMINATION OF OPTIMAL DEFICIT IRRIGATION STRATEGIES FOR YIELD AND YIELD COMPONENTS OF LAVENDER (LAVANDULA ANGUSTIFOLIA MILL.) IN SEMI-ARID CONDITIONS. Applied Ecology & Environmental Research. 2023;21(6).
  64. OA A-AA. Effect of altitude and nitrogen fertilization on some vegetative and flowering parameters and essential oil percentage of lavender plant (Lavandula angustifolia). Kirkuk University Journal For Agricultural Sciences. 2019;10(2):40-7.
  65. Sałata A, Buczkowska H, Nurzyńska-Wierdak R. Yield, essential oil content, and quality performance of Lavandula angustifolia leaves, as affected by supplementary irrigation and drying methods. Agriculture. 2020;10(12):590.
  66. Aprotosoaie AC, Gille E, Trifan A, Luca VS, Miron A. Essential oils of Lavandula genus: a systematic review of their chemistry. Phytochemistry Reviews. 2017;16:761-99.
  67. Danh LT, Han LN, Triet NDA, Zhao J, Mammucari R, Foster N. Comparison of chemical composition, antioxidant and antimicrobial activity of lavender (Lavandula angustifolia L.) essential oils extracted by supercritical CO 2, hexane and hydrodistillation. Food and bioprocess technology. 2013;6:3481-9.
  68. Binello A, Orio L, Pignata G, Nicola S, Chemat F, Cravotto G. Effect of microwaves on the in situ hydrodistillation of four different Lamiaceae. Comptes Rendus Chimie. 2014;17(3):181-6.
  69. Carrasco A, Martinez-Gutierrez R, Tomas V, Tudela J. Lavandula angustifolia and Lavandula latifolia essential oils from Spain: Aromatic profile and bioactivities. Planta Medica. 2016;82(01/02):163-70.
  70. Nedeltcheva-Antonova D, Gechovska K, Bozhanov S, Antonov L. Exploring the chemical composition of Bulgarian lavender absolute (Lavandula angustifolia Mill.) by GC/MS and GC-FID. Plants. 2022;11(22):3150.
  71. Bernard T, Perineau F, Delmas M, Gaset A. Extraction of Essential Oils. Part III. Two-Stage Production of the Oil of Lavandula angustifolia Mill. Journal of Essential Oil Research. 1989;1(6):261-7.
  72. Momtaz S, Abdolghaffari A, Jasemi E, Yaghoobvand B, Esmaeilzadeh S, Abdollahi A, Abdollahi M. Evaluation of wound healing and anti-inflammatory activities of a herbal ointment consisting of Althaea officinalis, Lavandula angustifolia, and Rosa x damascena in animal excision wound model. Journal of Medicinal Plants. 2021;20(77):37-49.
  73. Djemaa FGB, Bellassoued K, Zouari S, El Feki A, Ammar E. Antioxidant and wound healing activity of Lavandula aspic L. ointment. Journal of Tissue Viability. 2016;25(4):193-200.

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